Characterization of the retinoic acid-induced gene network responsible for pancreas specification in Xenopus laevis vorgelegt von Maja B. Gere 

Erscheinungsform: einbändiges Werk
Autor/Urheber:
  • Gere, Maja B.
Beteiligte:
  • Pieler, Tomas
  • Jäckle, Herbert
  • Wodarz, Andreas
  • Mansouri, Ahmed
  • Wimmer, Ernst
  • Dobbelstein, Matthias
Umfang: 1 Online-Ressource Illustrationen, Diagramme
Identifikatoren/​Sonstige Nummern: 879152982 [PPN]
Inhalt:
  • Retinoic acid (RA) is critically required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA-signaling in this context remains to be defined. We identified 22 RA-target genes through RNA-sequencing of in vitro generated pancreatic organoids. One of these is Hnf1b, which has been shown to be associated with a monogenic form of diabetes in humans and with pancreas hypoplasia in vertebrates. Functional analyses of Hnf1b in pancreatic organoids and whole Xenopus embryos revealed its early requirement for pancreatic progenitor fo...
URL: http://hdl.handle.net/11858/00-1735-0000-002B-7D30-D
Weiter im Partnersystem: https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=879152982
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