Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex Sarah Melzer, Magdalena Michael, Antonio Caputi, Marina Eliava, Elke C. Fuchs, Miles A. Whittington, Hannah Monyer 

Erscheinungsform: Aufsatz
Autor/Urheber:
  • Melzer, Sarah
Beteiligte:
  • Michael, Magdalena
  • Caputi, Antonio
  • Eliava, Marina
  • Fuchs, Elke C.
  • Monyer, Hannah
Umfang: 5
Anmerkungen: Gesehen am 17.09.2018
Identifikatoren/​Sonstige Nummern: 1581012705 [PPN]
In: Washington, DC [u.a.] : American Association for the Advancement of Science, 1880 335(2012), 6075, Seite 1506-1510 volume:335 year:2012 number:6075 pages:1506-1510 extent:5
Inhalt:
  • The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.
URL: http://dx.doi.org/10.1126/science.1217139
Weiter im Partnersystem: https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=1581012705
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