Connexin 36 promotes cortical spreading depolarization and ischemic brain damage Panagiotis Bargiotas, Sajjad Muhammad, Mahbubur Rahman, Nurith Jakob, Raimund Trabold, Elke Fuchs, Lothar Schilling, Nikolaus Plesnila, Hannah Monyer, Markus Schwaninger 

Erscheinungsform: Aufsatz
Autor/Urheber:
  • Bargiotas, Panagiotis
Beteiligte:
  • Muḥammad, Sajjad
  • Rahman, Mahbubur
  • Jakob, Nurith Juliane
  • Fuchs, Elke C.
  • Schilling, Lothar
  • Monyer, Hannah
  • Schwaninger, Markus
Umfang: 6
Anmerkungen: Available online 31 August 2012
Gesehen am 23.10.2018
Identifikatoren/​Sonstige Nummern: 1582184127 [PPN]
In: Amsterdam : Elsevier, 1966 1479(2012), Seite 80-85 volume:1479 year:2012 pages:80-85 extent:6
Inhalt:
  • Cortical spreading depolarization (CSD) promotes the progression of neuronal injury after cerebral ischemia. However, the mechanisms of propagation of postischemic CSD events are still unclear. In this study we characterized the role of the main neuronal gap junction protein connexin 36 (Cx36) in generating postischemic CSDs. In Cx36-deficient mice and controls we occluded the distal middle cerebral artery. To detect CSD events we recorded the direct current and laser Doppler flow. In addition, locomotor function and the infarct size were determined. Cx36-deficient mice had significantly fewer and shorter CSD events than wild-type controls. Additionally, Cx36 deletion is neuroprotective, leading to a better functional outcome and decreased infarct size after ischemia. These results suggest a detrimental role for Cx36 after ischemia, possibly by promoting CSD.
URL: http://dx.doi.org/10.1016/j.brainres.2012.08.046
Weiter im Partnersystem: https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=1582184127
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