Highly enantioselective copper-catalyzed alkylation of β-ketoesters and subsequent cyclization to spirolactones/bi-spirolactones Qing-Hai Deng, Hubert Wadepohl, and Lutz H. Gade

Erscheinungsform:	Aufsatz
Autor/Urheber:	Deng, Qing-Hai
Beteiligte:	Wadepohl, Hubert Gade, Lutz H.
Umfang:	4
Anmerkungen:	Gesehen am 27.02.2019
Identifikatoren/Sonstige Nummern:	1588171094 [PPN]
In:	American Chemical Society Washington, DC : ACS Publications, 1879 134(2012), 6, Seite 2946-2949 volume:134 year:2012 number:6 pages:2946-2949 extent:4
Inhalt:	Cu-catalyzed enantioselective alkylation of β-ketoesters using alcohols for in situ preparation of alkylating reagents is reported. A number of functionalized β-ketoesters containing a quaternary carbon stereocenter are obtained with up to 99% ee. The alkylation products derived from 2-substituted allylic alcohols or their corresponding iodides can then be converted to spirolactones, bi-spirolactones, and related chiral target products.
URL:	http://dx.doi.org/10.1021/ja211859w
Weiter im Partnersystem:	https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=1588171094

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