The Lac Operon A Short History of a Genetic Paradigm 

Erscheinungsform: einbändiges Werk
Autor/Urheber:
Umfang: 1 online resource (216 pages)
Anmerkungen: Description based on publisher supplied metadata and other sources
Identifikatoren/​Sonstige Nummern: 1658100190 [PPN]
978-3-11-087947-6 [ISBN]
Inhalt:
  • Intro -- Introduction -- Part 1: A Short History of the lac System from its Beginning to 1978 -- 1.1 From Noah to Pasteur: Adaptation in Yeast -- 1.2 Adaptation in Bacillus subtilis and Escherichia coli -- 1.3 Mutants in the lac System of Escherichia coli -- 1.4 Inducers of the lac System and the Discovery of Permease -- 1.5 Negative Control through Repressor -- 1.6 Further Evidence for Negative Control through Repressor -- 1.7 The Triumph of the Jacob-Monod Theory -- 1.8 Minor Defects in the Jacob-Monod Theory -- 1.9 Isolation of the Lac and λ CI Repressors -- 1.10 Putting the lac Genes on Phage φ80 or λ -- 1.11 Lac and λ CI Repressors Bind to their Operator DNAs -- 1.12 Making Grams of Lac Repressor to Determine its Sequence -- 1.13 Mutations in lacI Suggest a Modular Structure of Repressor -- 1.14 Miller's Analysis of the I Gene: Climbing Mount Everest -- 1.15 Positive Control through the CAP Protein -- 1.16 Isolation and Sequence of lac Operator -- 1.17 Chemical DNA Sequencing -- 1.18 Steric Hindrance is the Mechanism of Repression -- 1.19 Chemical Synthesis of lac Operator DNA -- 1.20 Lac Repressor-Operator Complex Binds to Nitrocellulose -- 1.21 Polyacrylamide Gel Electrophoresis of Protein-DNA Complexes -- 1.22 Fusion of and Complementation within the lacZ Gene -- 1.23 Isolation of Lac Permease -- 1.24 The End of an Era -- Part 2: Misinterpretation -- 2.1 The Interpretation of Experiments is Sometimes Wrong -- 2.2 Adaptation Explained by Self-Replicating Genes -- 2.3 The Kinetics of Adaptation -- 2.4 Lac Repressor is RNA -- 2.5 Operator is RNA or Protein -- 2.6 Isolation of Lac Repressor -- 2.7 Isolation of Lac Permease and Arg Repressor -- 2.8 Genetic Proof that lac Operator is Dyadic -- 2.9 The Core of Lac Repressor Binds to lac Operator -- 2.10 Lac Repressor Uses ß-Sheet to Recognize lac Operator.
URL: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=3042054
Schlagwörter: Lactose-Operon, Forschung, Geschichte
Weiter im Partnersystem: https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=1658100190
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