International consensus definition of DNA methylation subgroups in juvenile myelomonocytic leukemia Maximilian Schönung, Julia Meyer, Peter Nöllke, Adam B. Olshen, Mark Hartmann, Norihiro Murakami, Manabu Wakamatsu, Yusuke Okuno, Christoph Plass, Mignon L. Loh, Charlotte M. Niemeyer, Hideki Muramatsu, Christian Flotho, Elliot Stieglitz and Daniel B. Lipka 

Erscheinungsform: Aufsatz
Autor/Urheber:
  • Schönung, Maximilian
Beteiligte:
  • Meyer, Julia
  • Nöllke, Peter
  • Olshen, Adam B.
  • Hartmann, Mark
  • Murakami, Norihiro
  • Wakamatsu, Manabu
  • Okuno, Yusuke
  • Plass, Christoph
  • Loh, Mignon L.
  • Niemeyer, Charlotte
  • Muramatsu, Hideki
  • Flotho, Christian
  • Stieglitz, Elliot
  • Lipka, Daniel
Umfang: 11
Anmerkungen: Published online first on November 2, 2020
Gesehen am 08.01.2021
Identifikatoren/​Sonstige Nummern: 173761023X [PPN]
In: Philadelphia, Pa. [u.a.] : AACR, 1995 27(2021), 1, Seite 158-168 volume:27 year:2021 number:1 pages:158-168 extent:11
Inhalt:
  • Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation (DNAme) patterns in JMML have correlated with outcome across multiple studies, suggesting it as a biomarker to improve patient stratification. However, standardized approaches to classify JMML based on DNAme patterns are lacking. We therefore sought to define an international consensus for DNAme subgroups in JMML and develop classification methods for clinical implementation.
URL: https://doi.org/10.1158/1078-0432.CCR-20-3184
Weiter im Partnersystem: https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=173761023X
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