Highly enantioselective copper-catalyzed electrophilic trifluoromethylation of β-ketoesters Qing-Hai Deng, Hubert Wadepohl, and Lutz H. Gade

Erscheinungsform:	Aufsatz
Autor/Urheber:	Deng, Qing-Hai
Beteiligte:	Wadepohl, Hubert Gade, Lutz H.
Umfang:	4
Anmerkungen:	Gesehen am 27.02.2019
Identifikatoren/Sonstige Nummern:	158817008X [PPN]
In:	American Chemical Society Washington, DC : ACS Publications, 1879 134(2012), 26, Seite 10769-10772 volume:134 year:2012 number:26 pages:10769-10772 extent:4
Inhalt:	Enantioselective Cu-catalyzed triﬂuoromethylation of β-ketoesters using commercially available triﬂuoromethylating reagents is reported. A number of αCF3 β-ketoesters are obtained with up to 99% ee. The triﬂuoromethylated products were then transformed diastereoselectively to α-CF3 β-hydroxyesters with two adjacent quaternary stereocenters via a Grignard reaction.
URL:	http://dx.doi.org/10.1021/ja3039773
Weiter im Partnersystem:	https://swb.bsz-bw.de/DB=2.1/PPNSET?PPN=158817008X

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